Still working to recover. Please don't edit quite yet.
Difference between revisions of "oxycodone"
m |
Anarchangel (Talk | contribs) (Undo revision 46331 by Broderick517848 (Talk) Vandalism by repeat SPA vandal) |
||
| Line 27: | Line 27: | ||
{{distinguish|oxytocin}} | {{distinguish|oxytocin}} | ||
| − | '''Oxycodone''' is an [ | + | '''Oxycodone''' is an [[opioid]] [[analgesic]] [[medication]] synthesized from [[thebaine]]. Its name is derived from [[codeine]] - the chemical structures are very similar, differing only in that the hydrogen on the codeine is oxidised to a hydroxyl group, hence 'oxy' and the hydroxyl group from the codeine becomes a ketone group, hence 'oxycodone.' |
The third difference to codeine is the 7,8-dihydro-feature (Codeine has a double-bond between those two carbons). | The third difference to codeine is the 7,8-dihydro-feature (Codeine has a double-bond between those two carbons). | ||
| − | It is effective orally and is marketed in combination with [ | + | It is effective orally and is marketed in combination with [[aspirin]] ('''Percodan''', '''Endodan''', '''Roxiprin''') or [[paracetamol]]/[[acetaminophen]] ('''Percocet''', '''Endocet''', '''Roxicet''', '''Tylox''') for the relief of [[Pain and nociception|pain]]. More recently, [[ibuprofen]] has been added to oxycodone ('''Combunox'''). It is also sold in a sustained-release form by [[Purdue Pharma]] under the trade name '''OxyContin''' as well as generic equivalents, and instant-release forms '''Endone''', '''OxyIR''', '''OxyNorm''', '''Percolone''', '''OxyFAST''', and '''Roxicodone'''. Roxicodone is available in 5, 15, and 30 [[Milligram|mg]] tablets. OxyContin is currently available in 5, 10, 15, 20, 30, 40, 45, 60, 80 and 160 [[Milligram|mg]] tablets<ref>[http://www.fda.gov/cder/foi/label/2006/020553s056lbl.pdf] Package Insert - OxyContin</ref> (although note that not all of these dosages are marketed in the USA) and, due to its sustained-release mechanism, is effective for eight to twelve hours. The 160 mg tablets were removed from sale due to problems with overdose, but have been re-introduced for limited use under strict medical supervision. Outside the U.S. OxyContin is also available in a 5 [[Milligram|mg]] tablet. On October 18, 2006, the FDA gave approval for three new dosage strengths, 15mg, 30mg, and 45mg<ref>[http://www.fda.gov/cder/foi/appletter/2006/020553s056ltr.pdf] New Drug Application - FDA</ref>. OxyNorm is available in 5, 10, and 20 mg capsules and tablets; also as a 1 mg/1 ml liquid in 250 ml bottles and as a 10 mg/1 ml concentrated liquid in 100 ml bottles. |
| − | In the United States, oxycodone is a Schedule II [ | + | In the United States, oxycodone is a Schedule II [[Controlled Substances Act|controlled substance]] both as a single agent and in combination with products containing acetaminophen, ibuprofen or aspirin. |
==Chemical structure== | ==Chemical structure== | ||
| − | The chemical structure of oxycodone is the methylether of [ | + | The chemical structure of oxycodone is the methylether of [[oxymorphone]]: 3-methyl-oxymorphone. It could also be described as 14-hydroxy-7,8-dihydro-[[codeinone]]. It is principally supplied as its hydrochloride salt: oxycodone hydrochloride. |
==Bioavailability== | ==Bioavailability== | ||
| − | Oxycodone can be administered orally, intranasally, via [ | + | Oxycodone can be administered orally, intranasally, via [[intravenous]]/[[intramuscular]]/[[subcutaneous]] injection, or rectally. The [[bioavailability]] of intranasal administration averages between 46-47%, but can be as much as 75%. Oral oxycodone is the most efficient means of administration, having an absorption of 60-87%. Rectal administration yields the same results. Injecting oxycodone will result in a stronger effect and quicker onset. <ref>[http://www.thatspoppycock.com/opiates/oxycodone.htm#pharm That's Poppycock! - Oxycodone: Pharmacology and Pharmacokinetics]</ref> ''' |
==Medical use== | ==Medical use== | ||
| − | [ | + | [[Image:Oxy512.jpg|thumb|right|Two oxycodone/[[paracetamol|APAP]] tablets]] |
| − | [ | + | [[Image:Oxycont.jpg|thumb|right|Oxycontin tablets of varying dose]] |
| − | Percocet tablets (Oxycodone with [ | + | Percocet tablets (Oxycodone with [[acetaminophen]]) are routinely prescribed for post-operative pain control. Oxycodone is also used in treatment of moderate to severe chronic pain. Both immediate release oxycodone and sustained-release oxycodone are now available (OxyContin and OxyNorm in the UK. There is no evidence that oxycodone is more effective than any other [[opioid]] and in palliative care [[morphine]] remains the gold standard. However, it can be useful as an alternative opioid if a patient has troublesome adverse effects with morphine. |
The potency ratio between oxycodone and morphine is still uncertain. The manufacturers claim oxycodone is twice as potent as morphine, but most studies show a much lower potency of between 1.3 to 1.7 times more potent, with an approximate mean of 1.5 time greater potency. | The potency ratio between oxycodone and morphine is still uncertain. The manufacturers claim oxycodone is twice as potent as morphine, but most studies show a much lower potency of between 1.3 to 1.7 times more potent, with an approximate mean of 1.5 time greater potency. | ||
| − | [ | + | [[Nausea]], [[drowsiness]], [[constipation]], [[lightheadedness]], [[rash]] or [[itchiness]], [[dizziness]], and [[emotional mood]] disorders are the most frequently reported side effects. Other side-effects can also include dry mouth and slightly decreased testosterone levels in men. Oxycodone accumulates in patients with renal or liver impairment and dose reductions may be needed. |
| − | As with all other [ | + | As with all other [[Opioids]] tolerance and dependence are rarely problems when these drugs are taken by patients in pain and given with the support of specialist in pain or [[palliative care]]. |
==History== | ==History== | ||
| − | Oxycodone is an opioid [ | + | Oxycodone is an opioid [[agonist]], and as such is a variation on an ancient theme beginning with the simple consumption or smoking of the alkaloid-bearing parts of ''Papaver somniferum'', the [[opium poppy]], first cultivated circa 3401 BC in lower Mesopotamia. Ancient Sumerians, Assyrians, Babylonians, and Egyptians found that smoking the extract derived from the seedpods yielded a pleasurable, peaceful feeling throughout the body. The Sumerians called the poppy plant "Hul Gil" or "joy plant". Cultivation and use spread quickly to the rest of the [[Levant]] and the Arabian Peninsula, eventually reaching India and China. |
| − | Oxycodone is a semi-synthetic opioid derived from the alkaloid [ | + | Oxycodone is a semi-synthetic opioid derived from the alkaloid [[thebaine]], unlike most early opium-derived drugs which instead used the [[morphine]] or [[codeine]] alkaloids also found in the plant. Oxycodone was first synthesized in a German laboratory in 1916, a few years after the German pharmaceutical company [[Bayer]] had stopped the mass production of [[heroin]] due to addiction and abuse by both patients and physicians. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less of the euphoric effect which led to addiction and over-use. To some extent this was achieved, as oxycodone does not "hit" the central nervous system with the same immediate punch as heroin or morphine do and it does not last as long. The subjective experience of a "high" was still reported for oxycodone, however, and it made its way into medical usage in small increments in most Western countries until the introduction of the OxyContin preparation radically boosted oxycodone use. |
==Recreational use== | ==Recreational use== | ||
{{Original research|section}} | {{Original research|section}} | ||
| − | The introduction of OxyContin in 1995 resulted in increasing patterns of abuse. Unlike Percocet, whose potential for abuse is limited by the presence of [ | + | The introduction of OxyContin in 1995 resulted in increasing patterns of abuse. Unlike Percocet, whose potential for abuse is limited by the presence of [[paracetamol]], OxyContin contains only oxycodone and inert filler. Abusers simply crush the tablets, then either ingest the resulting powder orally, intranasally, via [[intravenous]], [[intramuscular]] or [[subcutaneous]] injection (by dissolving the powder), or rectally to achieve rapid absorption into the bloodstream. Injection of OxyContin is particularly dangerous since it contains binders which enable the time release of the drug. Often mistaken as the time release, the outside coating of the pill is merely used as a color code for different dosage amounts,even though it can removed by saliva or wetness. The vast majority of OxyContin-related deaths are attributed to ingesting substantial quantities of oxycodone in combination with another depressant of the central nervous system such as [[ethanol|alcohol]] or [[benzodiazepines]]. While high doses of oxycodone can be fatal to an opiate-naïve individual in and of itself, lethal overdoses of only oxycodone rarely occur. It was once thought that opioids would be less subject to recreational (ab)use when one or more additional analgesics are added, since, for example, the amount of paracetamol present in higher doses of Percocet causes [[stomach]] upset and [[liver]] damage. However, it has been demonstrated that abusers seeking the euphoric "high" are not deterred by these potential side effects or toxicities. Abusers soon discovered that extremely simple methods to separate the ingredients exist, particularly due to the widely disparate solubility of the alkaloids and analgesics in water ("[[cold water extraction]]"). |
| − | [ | + | [[Image:OxySetup.JPG|thumb|right|Recreational Oxycodone Use]] |
| − | Oxycodone has similar effects to [ | + | Oxycodone has similar effects to [[morphine]] and [[heroin]], and appeals to the same abuse community. Armed robberies of pharmacies where the robber demanded only OxyContin, not cash, have occurred. In some areas, particularly the eastern U.S., OxyContin has been the drug of greatest concern to enforcement authorities, although trustworthy data on the actual incidence of "Oxy abuse" have been difficult to establish. |
| − | Because oxycodone is highly regulated, when acquired illegally it is quite expensive. [ | + | Because oxycodone is highly regulated, when acquired illegally it is quite expensive. [[Black market]] prices in [[Washington, DC]], and [[Portland, Maine]], for example, have been reported to reach upwards of one dollar per milligram, though it is more typical to pay $50 for an 80-milligram tablet on the streets of Washington. In parts of Kentucky, particularly in Appalachia, the cost is nearly $1.25/mg. Legally acquired OxyContin is however rather expensive, costing as much as 400 US dollars for a normal month supply. Again, in mid-2006, brand-name or similar-quality generic (''e.g.'', Watson, Purdue) eighty-milligram tablets sold for approximately nine dollars apiece whereas low-end generics (''e.g.'', Teva, referred to in slang as "footballs" after their shape) scarcely pushed five dollars. |
| − | In Australia OxyContin is covered by the [ | + | In Australia OxyContin is covered by the [[Pharmaceutical Benefits Scheme|PBS]], and a patient can potentially get up to sixty tablets for as little as $4.90AUD in total. This has led to Federal tightening of restrictions from May 2006 (see Regulation below). The 20mg tablet can fetch $30AUD-$50AUD on the Gold Coast black market. As such there are professional "Doctor shoppers" making a tidy profit each week from OxyContin. |
| − | Like other [ | + | Like other [[opioid]]s, oxycodone can be fatal at high doses or when combined with depressants such as [[ethanol|alcohol]] or [[Benzodiazapines|Benzodiazapines]]. Several documented fatalities from OxyContin abuse have been made public; however, these have done little to deter the combined use of the drug with other CNS depressants. |
| − | In early 2006 on the U.S. East Coast there were multiple anecdotal reports of "fake" OxyContin 80mg tablets, especially in Philadelphia and New York City. These fake OxyContin consisted mainly of sugar and were of poor quality, noting the distinct green color which differs from commercially made tablets.{{Fact|date=February 2007}} There have also been multiple reports of fake OxyContin 80mg tablets that contained [ | + | In early 2006 on the U.S. East Coast there were multiple anecdotal reports of "fake" OxyContin 80mg tablets, especially in Philadelphia and New York City. These fake OxyContin consisted mainly of sugar and were of poor quality, noting the distinct green color which differs from commercially made tablets.{{Fact|date=February 2007}} There have also been multiple reports of fake OxyContin 80mg tablets that contained [[Fentanyl]].<ref name="http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg0806/mg0806.html">[http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg0806/mg0806.html]</ref> |
| + | |||
| + | Illegal distribution of OxyContin occurs through pharmacy diversion, physicians, "[[doctor shopping]]," faked prescriptions, and robbery--all of which divert the pharmaceutical onto the illicit market. The increase of this situation coincides with the increase in the illegal use of this drug. The oxycodone contained in OxyContin produces typical opioid effects, and is considered a "reasonable substitute" for heroin, so much so that OxyContin is often referred to as "hillbilly heroin".<ref name="http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm">[http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm]</ref>. The most commonly diverted dosages are the 40mg and 80mg strengths<ref name="http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm">[http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm]</ref>. | ||
==Manufacturer and patents== | ==Manufacturer and patents== | ||
| − | [ | + | [[Image:Oxycodone varieties.jpg|frame|left|Formulations containing oxycodone and other analgesics.]] |
| − | OxyContin was first introduced onto the market by Purdue Pharma L.P. in 1995. This pharmaceutical company was founded in 1892 in New York City, and is currently a privately owned company that operates solely within the United States. The different branches within this company include, Purdue Pharma L.P., The Purdue Frederick Company, Purdue Pharmaceutical Products L.P., and Purdue Products L.P. (www.pharma.com). It has multiple patents for their drug OxyContin, but has recently been involved in a series of on going legal battles deciding on whether or not these patents are valid. On June 7th, 2005, the [ | + | OxyContin was first introduced onto the market by Purdue Pharma L.P. in 1995. This pharmaceutical company was founded in 1892 in New York City, and is currently a privately owned company that operates solely within the United States. The different branches within this company include, Purdue Pharma L.P., The Purdue Frederick Company, Purdue Pharmaceutical Products L.P., and Purdue Products L.P. (www.pharma.com). It has multiple patents for their drug OxyContin, but has recently been involved in a series of on going legal battles deciding on whether or not these patents are valid. On June 7th, 2005, the [[United States Court of Appeals for the Federal Circuit]] upheld a decision from the previous year that some of Purdue’s patents for OxyContin could not be enforced. This decision allowed and led to the immediate announcement from Endo Pharmaceutical Holdings, Inc. that they would begin launching a generic version of all four strengths of OxyContin<ref name="http://www.pharma.com/pressroom/news/20050608.htm">[http://www.pharma.com/pressroom/news/20050608.htm http://www.pharma.com/pressroom/news/20050608.htm]</ref>. Purdue, however, had already made negotiations with another pharmaceutical company (IVAX Pharmaceuticals) to distribute their brand OxyContin in a generic form. This contract was severed, and currently Watson Pharmaceuticals is the exclusive U.S. distributor of the generic versions of OxyContin Tablets. The agreement stipulates that "Purdue will manufacture and supply oxycodone HCI controlled-release tablets to Watson, which will market, sell, and distribute the authorized generic product in 10, 20, 40, and 80 milligram dosages in the United States"<ref name="http://www.pharma.com/pressroom/news/20051028.htm">[http://www.pharma.com/pressroom/news/20051028.htm http://www.pharma.com/pressroom/news/20051028.htm]</ref>. |
| − | Purdue Pharma L.P. is based out of Stamford, Connecticut, and is the site of the company’s headquarters. Manufacturing takes place at three different sites, which include: Purdue Pharmaceuticals L.P., a plant located in Wilson, North Carolina, The P.F. Laboratories Inc. in Totowa, New Jersey, and Rhodes Technologies L.P. located in Coventry, Rhode Island. Purdue Pharma L.P. also has research labs located in Cranbury, New Jersey. OxyContin is currently legally and illegally distributed throughout the U.S., Canada, and Mexico. Legal distribution takes place from the P.F. Laboratories Inc. in [ | + | Purdue Pharma L.P. is based out of Stamford, Connecticut, and is the site of the company’s headquarters. Manufacturing takes place at three different sites, which include: Purdue Pharmaceuticals L.P., a plant located in Wilson, North Carolina, The P.F. Laboratories Inc. in Totowa, New Jersey, and Rhodes Technologies L.P. located in Coventry, Rhode Island. Purdue Pharma L.P. also has research labs located in Cranbury, New Jersey. OxyContin is currently legally and illegally distributed throughout the U.S., Canada, and Mexico. Legal distribution takes place from the P.F. Laboratories Inc. in [[Totowa, New Jersey]]. Since the drug is a controlled substance, a prescription is required to obtain it, and is shown to be most frequently prescribed in the eastern U.S.<ref name="http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm">[http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm]</ref>. Purdue also exports OxyContin to wholesale distributors in Mexico and Canada. However, they have experienced increasing levels of illicit drug trafficking with the distribution outside of the U.S. that has led to certain responsive actions. The pill exported to Mexico is stamped with the letters "EX" instead of the customary "OC," and similarly the pills to [[Canada]] read "CDN." Purdue stopped exporting to Canada in 2001, and instead Canada imports the drug from a manufacturer in England. Despite these problems, OxyContin is one of the leading opioid painkillers on the market. In 2001, OxyContin was the highest sold drug of its kind, and in 2000, over 6.5 million prescriptions were written<ref name="http://www.drugpolicy.org/drugbydrug/oxycontin/">[http://www.drugpolicy.org/drugbydrug/oxycontin/ http://www.drugpolicy.org/drugbydrug/oxycontin/]</ref>. |
==Chemistry== | ==Chemistry== | ||
| − | Oxycodone is made, commercially, from [ | + | Oxycodone is made, commercially, from [[thebaine]], an [[opiate]] alkaloid and minor component of [[opium]]. Uniquely, it has stimulating properties, as compared to other [[opiates]], which is responsible for the subjective speedy quality of oxycodone some users report. The 14 hydroxy group increases potency by about 50% over [[hydrocodone]]. The 14 cinnamyl [[ester]] is 114x [[morphine]] in potency. |
==Regulation== | ==Regulation== | ||
| Line 89: | Line 91: | ||
In Australia a General Practitioner can prescribe for short term treatment without consulting another practitioner or government body. Ongoing treatment requires approval from their state Health Department. | In Australia a General Practitioner can prescribe for short term treatment without consulting another practitioner or government body. Ongoing treatment requires approval from their state Health Department. | ||
| − | Only twenty tablets are normally available per prescription on the [ | + | Only twenty tablets are normally available per prescription on the [[Pharmaceutical Benefits Scheme]], Australia's government-funded pharmaceutical insurance system. Prescriptions for larger quantities require prior approval from [[Medicare Australia]]. These prescriptions (i.e. for chronic pain or cancer patients) require the prescriber to have referred the patient to another medical practitioner to confirm the need for ongoing treatment with narcotic analgesics. |
Pharmacists must record all incoming purchases of oxycodone products, and maintain a register of all prescription sales for inspection by their state Health Department on request. In addition details of all Pharmaceutical Benefits Scheme prescriptions for oxycodone are sent to Medicare Australia. This data allows Medicare Australia to assist prescribers to identify doctor-shoppers via a telephone hotline. | Pharmacists must record all incoming purchases of oxycodone products, and maintain a register of all prescription sales for inspection by their state Health Department on request. In addition details of all Pharmaceutical Benefits Scheme prescriptions for oxycodone are sent to Medicare Australia. This data allows Medicare Australia to assist prescribers to identify doctor-shoppers via a telephone hotline. | ||
===Regulation in Canada=== | ===Regulation in Canada=== | ||
| − | In Canada, Oxycodone is a controlled substance under Schedule I of the [ | + | In Canada, Oxycodone is a controlled substance under Schedule I of the [[Controlled Drugs and Substances Act]] (CDSA). Every person who seeks or obtains the substance without disclosing authorization to obtain such substances 30 days prior to obtaining another prescription from a practitioner is guilty of an indictable offence and liable to imprisonment for a term not exceeding seven years. Possession for purpose of trafficking is guilty of an indictable offence and liable to imprisonment for life. |
===Regulation in Hong Kong=== | ===Regulation in Hong Kong=== | ||
| − | In [ | + | In [[Hong Kong]], oxycodone is regulated under Schedule 1 of [[Hong Kong|Hong Kong's]] Chapter 134 ''Dangerous Drugs Ordinance''. It can only be used legally by health professionals and for university research purposes. The substance can be be given by pharmacists under a prescription. Anyone who supplies the substance without a prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 ([[Hong Kong dollar|HKD]]) fine and/or life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time. |
===Regulation in the USA=== | ===Regulation in the USA=== | ||
| − | Regulation of prescription drugs comes from many different areas. The Food and Drug Administration (FDA) approves drugs for medical use, as well as sets regulations for the marketing of drugs, including controlled substances. The Drug Enforcement Administration (DEA) on the other hand, receives its regulatory authority from the Controlled Substances Act (CSA) [ | + | Regulation of prescription drugs comes from many different areas. The Food and Drug Administration (FDA) approves drugs for medical use, as well as sets regulations for the marketing of drugs, including controlled substances. The Drug Enforcement Administration (DEA) on the other hand, receives its regulatory authority from the Controlled Substances Act (CSA) [21 U.S.C. §§ 801-971], which "mandates that DEA prevent, detect and investigate the diversion of legally manufactured controlled substances while, at the same time, ensuring that there are adequate supplies to meet the legitimate medical needs in the United States"<ref name="http://www.deadiversion.usdoj.gov/drugs_concern/oxycodone/oxycontin_faq.htm">[http://www.deadiversion.usdoj.gov/drugs_concern/oxycodone/oxycontin_faq.htm http://www.deadiversion.usdoj.gov/drugs concern/oxycodone/oxycontin faq.htm]</ref>. |
| − | Part of the regulation of prescription drugs is connected to their marketing and advertising. The FDA has authority over this sector under the Food, Drug, and Cosmetic (FD&C) Act and its implementing regulations. The Division of Drug Marketing, Advertising, and Communications (DDMAC) is "responsible for regulating prescription drug advertising and promotion," and has a "mission is to protect the public health by ensuring that prescription drug information is truthful, balanced, and accurately communicated"<ref name="http://www.fda.gov/ola/2002/oxycontin0212.html">[http:// | + | Part of the regulation of prescription drugs is connected to their marketing and advertising. The FDA has authority over this sector under the Food, Drug, and Cosmetic (FD&C) Act and its implementing regulations. The Division of Drug Marketing, Advertising, and Communications (DDMAC) is "responsible for regulating prescription drug advertising and promotion," and has a "mission is to protect the public health by ensuring that prescription drug information is truthful, balanced, and accurately communicated"<ref name="http://www.fda.gov/ola/2002/oxycontin0212.html">[http://www.fda.gov/ola/2002/oxycontin0212.html http://www.fda.gov/ola/2002/oxycontin0212.html]</ref>. Simplified, Oxycodone is a schedule II controlled substance, which means to be filled there must be a written prescription which cannot have refills, nor can it be called in to a pharmacy by a physician. |
==Illicit Use== | ==Illicit Use== | ||
| − | OxyContin is becoming an increasingly more publicized and known drug to the general public. The discovery of its recreational benefits has led to an illicit underground market. Due to acts such as pharmacy diversion and "doctor shopping" the drug is widely available to those without a prescription. The increased misuse of the drug has led to a higher number of emergency department mentions and deaths associated with oxycodone<ref name="http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm">[http:// | + | OxyContin is becoming an increasingly more publicized and known drug to the general public. The discovery of its recreational benefits has led to an illicit underground market. Due to acts such as pharmacy diversion and "doctor shopping" the drug is widely available to those without a prescription. The increased misuse of the drug has led to a higher number of emergency department mentions and deaths associated with oxycodone<ref name="http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm">[http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm]</ref>. Between 1994 and 2001 there was a reported 352% increase in ER visits related to all forms of Oxycodone usage<ref name="Beardsley, P., Aceto, M., Cook, C., Bowman, E., Newman, J., & Harris, L. (2004). Discriminative Stimulus, Reinforcing, Physical Dependence, and Antinociceptive Effects of Oxycodone in Mice, Rats, and Rhesus Monkeys. Experimental and Clinical Psychopharmacology, 12(3), 163-172.">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15301633]</ref>. This is possibly in part due to the availability of Oxycontin beginning in 1995. Despite the increased efforts by the FDA, DEA, and state/local authorities, along with this negative publicity of the drug is not stopping its illicit use, but instead seems to be fueling the underground market. The Oxycontin tablets that are most commonly diverted and abused, are the 40mg tablets, which sell on the black market for approximately $15-40 per tablet. Abusers either: insufflate (snort), inject, chew, or smoke the tablets - as these methods of consumption destroy the built-in time release and give the user all of the drug at once, resulting in a euphoric and blissful rush; however, this can be dangerous, as far more oxycodone is released than medically safe. Though the drug has become increasingly popular with illicit users, it is very rare to be tested for in a drug test. This drug will be dectable in Urine for 4-5 days. Also, the opiate drug tests usually test primarily for Morphine and since Morphine is not a major metabolite of oxycodone, tests usually fail to detect low to moderate Oxycodone use. Direct tests for Oxycodone are possible but rare unless illicit use is suspected. |
==In Popular Culture== | ==In Popular Culture== | ||
| − | [ | + | [[Leonardo Dicaprio]]'s character in [[Martin Scorsese]]'s 2006 crime film ''[[The Departed]]'' finds a bottle that reads 'Oxycontin' in a relative's home. He then ingests a number of pills. Although the pills shown in the movie are not the correct size or shape as oxycontin, the bottle reads "oxycontin". |
| − | Many songs by rap artist [ | + | Many songs by rap artist [[Lil Wyte]], particularly Oxycontin and nearly every other song on his CD [[Doubt Me Now]] mention use of oxycontin. His more recent CD Phinally Phamous sees a decrease in mention of oxycodone and other pain medication drugs for recreational use. |
| − | In the ''[ | + | In the ''[[Drawn Together]]'' episode "[[Captain Girl]]", [[Captain Hero]] references using OxyContin before flying drunkenly into a tree. "If I wanted to slow down, I'd take another (said very slowly) OxyContin." |
| − | In one episode of the television show [ | + | In one episode of the television show [[Degrassi:The Next Generation]], [[JT Yorke]] sells oxycodone to help pay for the apartment he and his pregnant girlfriend, Liberty, were going to rent. In the ending, he overdoses on oxycodone and he is put on suicide watch. |
| − | In the [ | + | In the [[Gym Class Heroes]] song "Pillmatic" on the CD [[The Papercut Chronicles]] lead singer [[Travis McCoy]] refers to a number of drugs. OxyContin was specifically mentioned in the chorus and the second verse. "The OxyContin got my stomach rottin'." "OxyContin, orange juice, and gin equals projectile wild-style burner on the porceline." |
| − | In episode 10 of season 3 of the television show [ | + | In episode 10 of season 3 of the television show [[House (TV series)|House]], Dr. House steals a prescription medicine of Oxycodone from one of Dr. Wilson's patients to relieve him of the pain from his withdrawal from Vicodin |
| − | In the [ | + | In the [[Fall of Troy]] song "Dark Trail", Timothy Ward refers to OxyContin when he sings "I can pick you up and undress you. |
Take your blue dress off and mess me up tonight". This is a reference to the colour coded case on the pills that is commonly mistaken for a time release and removed. There are a number of other drug references in the song, and the entire "Manipulator" album which could be about OxyContin. | Take your blue dress off and mess me up tonight". This is a reference to the colour coded case on the pills that is commonly mistaken for a time release and removed. There are a number of other drug references in the song, and the entire "Manipulator" album which could be about OxyContin. | ||
| Line 130: | Line 132: | ||
Critics have long accused Purdue Frederick of putting profits ahead of public interest and lying about the addictive potential of the wildly popular, hot-selling, and highly-abused drug. | Critics have long accused Purdue Frederick of putting profits ahead of public interest and lying about the addictive potential of the wildly popular, hot-selling, and highly-abused drug. | ||
| − | On May 10th 2007, the Stamford, Connecticut-based The Purdue Frederick Company, Inc., pleaded guilty to felony charges that they purposely misbranded the painkiller OxyContin with intent to mislead and defraud. Purdue and the three executives will pay a total of $634,515,475. The drug company pleaded guilty to felony misbranding OxyContin with the intent to defraud and mislead. President and Chief Operating Officer Michael Friedman, Executive Vice President and Chief Legal Officer Howard Udell, and former Executive Vice President of Worldwide Medical Affairs Paul D. Goldenheim, pleaded guilty to a misdemeanor charge of misbranding OxyContin.<ref>[http:// | + | On May 10th 2007, the Stamford, Connecticut-based The Purdue Frederick Company, Inc., pleaded guilty to felony charges that they purposely misbranded the painkiller OxyContin with intent to mislead and defraud. Purdue and the three executives will pay a total of $634,515,475. The drug company pleaded guilty to felony misbranding OxyContin with the intent to defraud and mislead. President and Chief Operating Officer Michael Friedman, Executive Vice President and Chief Legal Officer Howard Udell, and former Executive Vice President of Worldwide Medical Affairs Paul D. Goldenheim, pleaded guilty to a misdemeanor charge of misbranding OxyContin.<ref>[http://www.legalnewsline.com/news/194919-purdue-pleads-guilty-will-pay-634-million-in-fines]</ref> The pleas were entered in United States District Court in Abingdon. |
The Purdue Frederick Company, Inc., and the three executives have admitted that Purdue fraudulently marketed OxyContin by falsely claiming that OxyContin was less addictive, less subject to abuse, and less likely to cause withdrawal symptoms than other pain medications when there was no medical research to support these claims and without Food and Drug Administration approval of these claims. | The Purdue Frederick Company, Inc., and the three executives have admitted that Purdue fraudulently marketed OxyContin by falsely claiming that OxyContin was less addictive, less subject to abuse, and less likely to cause withdrawal symptoms than other pain medications when there was no medical research to support these claims and without Food and Drug Administration approval of these claims. | ||
| − | <ref>[http:// | + | <ref>[http://www.usdoj.gov/usao/vaw/press_releases/purdue_frederick_10may2007.html United States Attorney's Office Western District Of Virginia]</ref> |
==See also== | ==See also== | ||
| − | * [ | + | * [[Opioids]] |
| − | * [ | + | * [[Codeine]] |
| − | * [http:// | + | * [[Drug addiction]] |
| − | * [http:// | + | * [[Thebaine]] |
| − | * [http:// | + | |
| + | ==References== | ||
| + | <references/> | ||
| + | |||
| + | ==External links== | ||
| + | * [http://www.minervamedica.it/pdf/R02Y2005/R02Y2005N07A0451.pdf Oxycodone: Pharmacological profile and clinical data in chronic pain management] ''minervamedica.it.'' Minerva Anestesiologica, 2005;71:451-60. [pdf file] | ||
| + | * [http://www.drugs.com/pdr/percocet_tablets.html Percocet Drug Information] from Thomson Healthcare database | ||
| + | * [http://www.addictionsearch.com/treatment_articles/article/oxycodone-addiction_14.html Article on Oxycodone Addiction] | ||
{{ChemicalSources}} | {{ChemicalSources}} | ||
| − | * [http:// | + | * [http://www.reuters.com/article/healthNews/idUSWBT00695020070510?src=051007_1225_DOUBLEFEATURE_ Oxycontin makers and executives plead guilty to coverup of dangers and addictive qualities |
{{wikipedia|Oxycodone}} | {{wikipedia|Oxycodone}} | ||
| − | [ | + | [[Category:Morphinans]] |
| + | [[Category:Semisynthetic opioids]] | ||
Revision as of 20:04, 21 February 2011
Template:drugbox Template:distinguish
Oxycodone is an opioid analgesic medication synthesized from thebaine. Its name is derived from codeine - the chemical structures are very similar, differing only in that the hydrogen on the codeine is oxidised to a hydroxyl group, hence 'oxy' and the hydroxyl group from the codeine becomes a ketone group, hence 'oxycodone.' The third difference to codeine is the 7,8-dihydro-feature (Codeine has a double-bond between those two carbons).
It is effective orally and is marketed in combination with aspirin (Percodan, Endodan, Roxiprin) or paracetamol/acetaminophen (Percocet, Endocet, Roxicet, Tylox) for the relief of pain. More recently, ibuprofen has been added to oxycodone (Combunox). It is also sold in a sustained-release form by Purdue Pharma under the trade name OxyContin as well as generic equivalents, and instant-release forms Endone, OxyIR, OxyNorm, Percolone, OxyFAST, and Roxicodone. Roxicodone is available in 5, 15, and 30 mg tablets. OxyContin is currently available in 5, 10, 15, 20, 30, 40, 45, 60, 80 and 160 mg tablets[1] (although note that not all of these dosages are marketed in the USA) and, due to its sustained-release mechanism, is effective for eight to twelve hours. The 160 mg tablets were removed from sale due to problems with overdose, but have been re-introduced for limited use under strict medical supervision. Outside the U.S. OxyContin is also available in a 5 mg tablet. On October 18, 2006, the FDA gave approval for three new dosage strengths, 15mg, 30mg, and 45mg[2]. OxyNorm is available in 5, 10, and 20 mg capsules and tablets; also as a 1 mg/1 ml liquid in 250 ml bottles and as a 10 mg/1 ml concentrated liquid in 100 ml bottles.
In the United States, oxycodone is a Schedule II controlled substance both as a single agent and in combination with products containing acetaminophen, ibuprofen or aspirin.
Contents
Chemical structure
The chemical structure of oxycodone is the methylether of oxymorphone: 3-methyl-oxymorphone. It could also be described as 14-hydroxy-7,8-dihydro-codeinone. It is principally supplied as its hydrochloride salt: oxycodone hydrochloride.
Bioavailability
Oxycodone can be administered orally, intranasally, via intravenous/intramuscular/subcutaneous injection, or rectally. The bioavailability of intranasal administration averages between 46-47%, but can be as much as 75%. Oral oxycodone is the most efficient means of administration, having an absorption of 60-87%. Rectal administration yields the same results. Injecting oxycodone will result in a stronger effect and quicker onset. [3]
Medical use
Percocet tablets (Oxycodone with acetaminophen) are routinely prescribed for post-operative pain control. Oxycodone is also used in treatment of moderate to severe chronic pain. Both immediate release oxycodone and sustained-release oxycodone are now available (OxyContin and OxyNorm in the UK. There is no evidence that oxycodone is more effective than any other opioid and in palliative care morphine remains the gold standard. However, it can be useful as an alternative opioid if a patient has troublesome adverse effects with morphine.
The potency ratio between oxycodone and morphine is still uncertain. The manufacturers claim oxycodone is twice as potent as morphine, but most studies show a much lower potency of between 1.3 to 1.7 times more potent, with an approximate mean of 1.5 time greater potency.
Nausea, drowsiness, constipation, lightheadedness, rash or itchiness, dizziness, and emotional mood disorders are the most frequently reported side effects. Other side-effects can also include dry mouth and slightly decreased testosterone levels in men. Oxycodone accumulates in patients with renal or liver impairment and dose reductions may be needed.
As with all other Opioids tolerance and dependence are rarely problems when these drugs are taken by patients in pain and given with the support of specialist in pain or palliative care.
History
Oxycodone is an opioid agonist, and as such is a variation on an ancient theme beginning with the simple consumption or smoking of the alkaloid-bearing parts of Papaver somniferum, the opium poppy, first cultivated circa 3401 BC in lower Mesopotamia. Ancient Sumerians, Assyrians, Babylonians, and Egyptians found that smoking the extract derived from the seedpods yielded a pleasurable, peaceful feeling throughout the body. The Sumerians called the poppy plant "Hul Gil" or "joy plant". Cultivation and use spread quickly to the rest of the Levant and the Arabian Peninsula, eventually reaching India and China.
Oxycodone is a semi-synthetic opioid derived from the alkaloid thebaine, unlike most early opium-derived drugs which instead used the morphine or codeine alkaloids also found in the plant. Oxycodone was first synthesized in a German laboratory in 1916, a few years after the German pharmaceutical company Bayer had stopped the mass production of heroin due to addiction and abuse by both patients and physicians. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less of the euphoric effect which led to addiction and over-use. To some extent this was achieved, as oxycodone does not "hit" the central nervous system with the same immediate punch as heroin or morphine do and it does not last as long. The subjective experience of a "high" was still reported for oxycodone, however, and it made its way into medical usage in small increments in most Western countries until the introduction of the OxyContin preparation radically boosted oxycodone use.
Recreational use
The introduction of OxyContin in 1995 resulted in increasing patterns of abuse. Unlike Percocet, whose potential for abuse is limited by the presence of paracetamol, OxyContin contains only oxycodone and inert filler. Abusers simply crush the tablets, then either ingest the resulting powder orally, intranasally, via intravenous, intramuscular or subcutaneous injection (by dissolving the powder), or rectally to achieve rapid absorption into the bloodstream. Injection of OxyContin is particularly dangerous since it contains binders which enable the time release of the drug. Often mistaken as the time release, the outside coating of the pill is merely used as a color code for different dosage amounts,even though it can removed by saliva or wetness. The vast majority of OxyContin-related deaths are attributed to ingesting substantial quantities of oxycodone in combination with another depressant of the central nervous system such as alcohol or benzodiazepines. While high doses of oxycodone can be fatal to an opiate-naïve individual in and of itself, lethal overdoses of only oxycodone rarely occur. It was once thought that opioids would be less subject to recreational (ab)use when one or more additional analgesics are added, since, for example, the amount of paracetamol present in higher doses of Percocet causes stomach upset and liver damage. However, it has been demonstrated that abusers seeking the euphoric "high" are not deterred by these potential side effects or toxicities. Abusers soon discovered that extremely simple methods to separate the ingredients exist, particularly due to the widely disparate solubility of the alkaloids and analgesics in water ("cold water extraction").
Oxycodone has similar effects to morphine and heroin, and appeals to the same abuse community. Armed robberies of pharmacies where the robber demanded only OxyContin, not cash, have occurred. In some areas, particularly the eastern U.S., OxyContin has been the drug of greatest concern to enforcement authorities, although trustworthy data on the actual incidence of "Oxy abuse" have been difficult to establish.
Because oxycodone is highly regulated, when acquired illegally it is quite expensive. Black market prices in Washington, DC, and Portland, Maine, for example, have been reported to reach upwards of one dollar per milligram, though it is more typical to pay $50 for an 80-milligram tablet on the streets of Washington. In parts of Kentucky, particularly in Appalachia, the cost is nearly $1.25/mg. Legally acquired OxyContin is however rather expensive, costing as much as 400 US dollars for a normal month supply. Again, in mid-2006, brand-name or similar-quality generic (e.g., Watson, Purdue) eighty-milligram tablets sold for approximately nine dollars apiece whereas low-end generics (e.g., Teva, referred to in slang as "footballs" after their shape) scarcely pushed five dollars.
In Australia OxyContin is covered by the PBS, and a patient can potentially get up to sixty tablets for as little as $4.90AUD in total. This has led to Federal tightening of restrictions from May 2006 (see Regulation below). The 20mg tablet can fetch $30AUD-$50AUD on the Gold Coast black market. As such there are professional "Doctor shoppers" making a tidy profit each week from OxyContin.
Like other opioids, oxycodone can be fatal at high doses or when combined with depressants such as alcohol or Benzodiazapines. Several documented fatalities from OxyContin abuse have been made public; however, these have done little to deter the combined use of the drug with other CNS depressants.
In early 2006 on the U.S. East Coast there were multiple anecdotal reports of "fake" OxyContin 80mg tablets, especially in Philadelphia and New York City. These fake OxyContin consisted mainly of sugar and were of poor quality, noting the distinct green color which differs from commercially made tablets.[unverified] There have also been multiple reports of fake OxyContin 80mg tablets that contained Fentanyl.[4]
Illegal distribution of OxyContin occurs through pharmacy diversion, physicians, "doctor shopping," faked prescriptions, and robbery--all of which divert the pharmaceutical onto the illicit market. The increase of this situation coincides with the increase in the illegal use of this drug. The oxycodone contained in OxyContin produces typical opioid effects, and is considered a "reasonable substitute" for heroin, so much so that OxyContin is often referred to as "hillbilly heroin".[5]. The most commonly diverted dosages are the 40mg and 80mg strengths[5].
Manufacturer and patents
OxyContin was first introduced onto the market by Purdue Pharma L.P. in 1995. This pharmaceutical company was founded in 1892 in New York City, and is currently a privately owned company that operates solely within the United States. The different branches within this company include, Purdue Pharma L.P., The Purdue Frederick Company, Purdue Pharmaceutical Products L.P., and Purdue Products L.P. (www.pharma.com). It has multiple patents for their drug OxyContin, but has recently been involved in a series of on going legal battles deciding on whether or not these patents are valid. On June 7th, 2005, the United States Court of Appeals for the Federal Circuit upheld a decision from the previous year that some of Purdue’s patents for OxyContin could not be enforced. This decision allowed and led to the immediate announcement from Endo Pharmaceutical Holdings, Inc. that they would begin launching a generic version of all four strengths of OxyContin[6]. Purdue, however, had already made negotiations with another pharmaceutical company (IVAX Pharmaceuticals) to distribute their brand OxyContin in a generic form. This contract was severed, and currently Watson Pharmaceuticals is the exclusive U.S. distributor of the generic versions of OxyContin Tablets. The agreement stipulates that "Purdue will manufacture and supply oxycodone HCI controlled-release tablets to Watson, which will market, sell, and distribute the authorized generic product in 10, 20, 40, and 80 milligram dosages in the United States"[7].
Purdue Pharma L.P. is based out of Stamford, Connecticut, and is the site of the company’s headquarters. Manufacturing takes place at three different sites, which include: Purdue Pharmaceuticals L.P., a plant located in Wilson, North Carolina, The P.F. Laboratories Inc. in Totowa, New Jersey, and Rhodes Technologies L.P. located in Coventry, Rhode Island. Purdue Pharma L.P. also has research labs located in Cranbury, New Jersey. OxyContin is currently legally and illegally distributed throughout the U.S., Canada, and Mexico. Legal distribution takes place from the P.F. Laboratories Inc. in Totowa, New Jersey. Since the drug is a controlled substance, a prescription is required to obtain it, and is shown to be most frequently prescribed in the eastern U.S.[5]. Purdue also exports OxyContin to wholesale distributors in Mexico and Canada. However, they have experienced increasing levels of illicit drug trafficking with the distribution outside of the U.S. that has led to certain responsive actions. The pill exported to Mexico is stamped with the letters "EX" instead of the customary "OC," and similarly the pills to Canada read "CDN." Purdue stopped exporting to Canada in 2001, and instead Canada imports the drug from a manufacturer in England. Despite these problems, OxyContin is one of the leading opioid painkillers on the market. In 2001, OxyContin was the highest sold drug of its kind, and in 2000, over 6.5 million prescriptions were written[8].
Chemistry
Oxycodone is made, commercially, from thebaine, an opiate alkaloid and minor component of opium. Uniquely, it has stimulating properties, as compared to other opiates, which is responsible for the subjective speedy quality of oxycodone some users report. The 14 hydroxy group increases potency by about 50% over hydrocodone. The 14 cinnamyl ester is 114x morphine in potency.
Regulation
Regulation of oxycodone (and opioids in general) differs according to country, with different places focusing on different parts of the "supply chain".
Regulation in Australia
In Australia a General Practitioner can prescribe for short term treatment without consulting another practitioner or government body. Ongoing treatment requires approval from their state Health Department.
Only twenty tablets are normally available per prescription on the Pharmaceutical Benefits Scheme, Australia's government-funded pharmaceutical insurance system. Prescriptions for larger quantities require prior approval from Medicare Australia. These prescriptions (i.e. for chronic pain or cancer patients) require the prescriber to have referred the patient to another medical practitioner to confirm the need for ongoing treatment with narcotic analgesics.
Pharmacists must record all incoming purchases of oxycodone products, and maintain a register of all prescription sales for inspection by their state Health Department on request. In addition details of all Pharmaceutical Benefits Scheme prescriptions for oxycodone are sent to Medicare Australia. This data allows Medicare Australia to assist prescribers to identify doctor-shoppers via a telephone hotline.
Regulation in Canada
In Canada, Oxycodone is a controlled substance under Schedule I of the Controlled Drugs and Substances Act (CDSA). Every person who seeks or obtains the substance without disclosing authorization to obtain such substances 30 days prior to obtaining another prescription from a practitioner is guilty of an indictable offence and liable to imprisonment for a term not exceeding seven years. Possession for purpose of trafficking is guilty of an indictable offence and liable to imprisonment for life.
Regulation in Hong Kong
In Hong Kong, oxycodone is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purposes. The substance can be be given by pharmacists under a prescription. Anyone who supplies the substance without a prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and/or life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
Regulation in the USA
Regulation of prescription drugs comes from many different areas. The Food and Drug Administration (FDA) approves drugs for medical use, as well as sets regulations for the marketing of drugs, including controlled substances. The Drug Enforcement Administration (DEA) on the other hand, receives its regulatory authority from the Controlled Substances Act (CSA) [21 U.S.C. §§ 801-971], which "mandates that DEA prevent, detect and investigate the diversion of legally manufactured controlled substances while, at the same time, ensuring that there are adequate supplies to meet the legitimate medical needs in the United States"[9].
Part of the regulation of prescription drugs is connected to their marketing and advertising. The FDA has authority over this sector under the Food, Drug, and Cosmetic (FD&C) Act and its implementing regulations. The Division of Drug Marketing, Advertising, and Communications (DDMAC) is "responsible for regulating prescription drug advertising and promotion," and has a "mission is to protect the public health by ensuring that prescription drug information is truthful, balanced, and accurately communicated"[10]. Simplified, Oxycodone is a schedule II controlled substance, which means to be filled there must be a written prescription which cannot have refills, nor can it be called in to a pharmacy by a physician.
Illicit Use
OxyContin is becoming an increasingly more publicized and known drug to the general public. The discovery of its recreational benefits has led to an illicit underground market. Due to acts such as pharmacy diversion and "doctor shopping" the drug is widely available to those without a prescription. The increased misuse of the drug has led to a higher number of emergency department mentions and deaths associated with oxycodone[5]. Between 1994 and 2001 there was a reported 352% increase in ER visits related to all forms of Oxycodone usage[11]. This is possibly in part due to the availability of Oxycontin beginning in 1995. Despite the increased efforts by the FDA, DEA, and state/local authorities, along with this negative publicity of the drug is not stopping its illicit use, but instead seems to be fueling the underground market. The Oxycontin tablets that are most commonly diverted and abused, are the 40mg tablets, which sell on the black market for approximately $15-40 per tablet. Abusers either: insufflate (snort), inject, chew, or smoke the tablets - as these methods of consumption destroy the built-in time release and give the user all of the drug at once, resulting in a euphoric and blissful rush; however, this can be dangerous, as far more oxycodone is released than medically safe. Though the drug has become increasingly popular with illicit users, it is very rare to be tested for in a drug test. This drug will be dectable in Urine for 4-5 days. Also, the opiate drug tests usually test primarily for Morphine and since Morphine is not a major metabolite of oxycodone, tests usually fail to detect low to moderate Oxycodone use. Direct tests for Oxycodone are possible but rare unless illicit use is suspected.
In Popular Culture
Leonardo Dicaprio's character in Martin Scorsese's 2006 crime film The Departed finds a bottle that reads 'Oxycontin' in a relative's home. He then ingests a number of pills. Although the pills shown in the movie are not the correct size or shape as oxycontin, the bottle reads "oxycontin".
Many songs by rap artist Lil Wyte, particularly Oxycontin and nearly every other song on his CD Doubt Me Now mention use of oxycontin. His more recent CD Phinally Phamous sees a decrease in mention of oxycodone and other pain medication drugs for recreational use.
In the Drawn Together episode "Captain Girl", Captain Hero references using OxyContin before flying drunkenly into a tree. "If I wanted to slow down, I'd take another (said very slowly) OxyContin."
In one episode of the television show Degrassi:The Next Generation, JT Yorke sells oxycodone to help pay for the apartment he and his pregnant girlfriend, Liberty, were going to rent. In the ending, he overdoses on oxycodone and he is put on suicide watch.
In the Gym Class Heroes song "Pillmatic" on the CD The Papercut Chronicles lead singer Travis McCoy refers to a number of drugs. OxyContin was specifically mentioned in the chorus and the second verse. "The OxyContin got my stomach rottin'." "OxyContin, orange juice, and gin equals projectile wild-style burner on the porceline."
In episode 10 of season 3 of the television show House, Dr. House steals a prescription medicine of Oxycodone from one of Dr. Wilson's patients to relieve him of the pain from his withdrawal from Vicodin
In the Fall of Troy song "Dark Trail", Timothy Ward refers to OxyContin when he sings "I can pick you up and undress you.
Take your blue dress off and mess me up tonight". This is a reference to the colour coded case on the pills that is commonly mistaken for a time release and removed. There are a number of other drug references in the song, and the entire "Manipulator" album which could be about OxyContin.
Controversies
Template:Unreferenced Critics have long accused Purdue Frederick of putting profits ahead of public interest and lying about the addictive potential of the wildly popular, hot-selling, and highly-abused drug.
On May 10th 2007, the Stamford, Connecticut-based The Purdue Frederick Company, Inc., pleaded guilty to felony charges that they purposely misbranded the painkiller OxyContin with intent to mislead and defraud. Purdue and the three executives will pay a total of $634,515,475. The drug company pleaded guilty to felony misbranding OxyContin with the intent to defraud and mislead. President and Chief Operating Officer Michael Friedman, Executive Vice President and Chief Legal Officer Howard Udell, and former Executive Vice President of Worldwide Medical Affairs Paul D. Goldenheim, pleaded guilty to a misdemeanor charge of misbranding OxyContin.[12] The pleas were entered in United States District Court in Abingdon. The Purdue Frederick Company, Inc., and the three executives have admitted that Purdue fraudulently marketed OxyContin by falsely claiming that OxyContin was less addictive, less subject to abuse, and less likely to cause withdrawal symptoms than other pain medications when there was no medical research to support these claims and without Food and Drug Administration approval of these claims. [13]
See also
References
- ↑ [1] Package Insert - OxyContin
- ↑ [2] New Drug Application - FDA
- ↑ That's Poppycock! - Oxycodone: Pharmacology and Pharmacokinetics
- ↑ [3]
- ↑ 5.0 5.1 5.2 5.3 http://police.byu.edu/community%20education/drugalert/oxycontinfacts.htm
- ↑ http://www.pharma.com/pressroom/news/20050608.htm
- ↑ http://www.pharma.com/pressroom/news/20051028.htm
- ↑ http://www.drugpolicy.org/drugbydrug/oxycontin/
- ↑ http://www.deadiversion.usdoj.gov/drugs concern/oxycodone/oxycontin faq.htm
- ↑ http://www.fda.gov/ola/2002/oxycontin0212.html
- ↑ [4]
- ↑ [5]
- ↑ United States Attorney's Office Western District Of Virginia
External links
- Oxycodone: Pharmacological profile and clinical data in chronic pain management minervamedica.it. Minerva Anestesiologica, 2005;71:451-60. [pdf file]
- Percocet Drug Information from Thomson Healthcare database
- Article on Oxycodone Addiction
- [http://www.reuters.com/article/healthNews/idUSWBT00695020070510?src=051007_1225_DOUBLEFEATURE_ Oxycontin makers and executives plead guilty to coverup of dangers and addictive qualities
| This article contains content from Wikipedia. Current versions of the GNU FDL article Oxycodone on WP may contain information useful to the improvement of this article | WP |
