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5-alpha reductase
From Anarchopedia
5-alpha reductase is an enzyme (EC 1.3.99.5) that converts testosterone, the male sex hormone, into dihydrotestosterone. There are two isoenzymes, steroid 5-alpha reductase 1 and 2 (SRD5A1 and SRD5A2). The second isoenzyme is deficient in 5-alpha-reductase deficiency, which leads to a form of intersexualism.
Genetics[edit]
SRD5A1 is located on chromosome 5p15, while SRD5A2 is located on 2p23.
Pharmacology[edit]
Finasteride inhibits the function of only one of the isoenzymes (type 1), while dutasteride inhibits both forms. These drugs are used in benign prostatic hyperplasia, prostate cancer and baldness (finasteride).
